Soft materials are materials of choice in diverse modern technologies with applications including tissue adhesives, bioelectronics, and soft robots, as well as in traditional technologies such as tires and vibration isolators. In all these technologies, the mechanical and physical properties of soft materials play an important role, which are governed by phenomena spanning from the nanometer single-chain level, the mesoscale network level, to the macro-scale bulk material level. Specifically, large deformations coupled with various multi-physical phenomena and instabilities at different length scales open an immensely rich research arena for computational mechanics approaches. Additive and multi-material manufacturing adds another layer of complexity for problems in soft materials. Moreover, soft materials represent essential components in biological tissues, a topic of extreme interest for biomedical applications. These problems require the development of a unique suite of computational approaches that have to deviate from their traditional counterparts in hard materials due to the inherent nonlinearities in the response of these materials. This mini-symposium aims to bring together scientists and engineers working at the forefront of soft matter modeling to exchange and share their experiences and recent research results. Topics of interest include, but are not limited to: • First-principles modeling and multiscale methods: Ab-initio simulations; molecular or micro to macro homogenization/upscaling/coarse-graining methods; • Data-driven and machine learning methods: supervised and unsupervised learning of constitutive models from experimental data; novel neural network architectures for solving equilibrium equations; surrogate modeling; • Multiphysics modeling: computational methods for coupled electro-mechanical-chemical problems, bio-inspired materials, active soft materials; methods for complex applications such as implants, wearable devices, 3D printing; methods for growth and remodeling in tissues; inverse methods for design of multiphysics systems; • Adhesion, friction, contact problems in soft matter: instabilities and failure in thin films and interfaces; surface tension and capillary effects; novel contact algorithms for highly deformable materials; • Fracture in soft matter: novel computational method development; homogenization of fracture; phase-field methods • Integration of computational methods with experimental methods in soft matter.