The objective of this mini-symposium is to bring together experts from academia, industry and national labs to discuss the most recent advances and emerging research directions in the field of stabilized and variational multiscale (VMS) methods, which play a crucial role in the accurate and efficient numerical modeling of complex fluid mechanics problems. The symposium will cover theoretical developments, efficient numerical schemes, multiphysics coupling, adaptive strategies, novel mesh-moving techniques, embedded formulations, advanced discretization approaches, error estimation, uncertainty quantification, reduced-order modeling, and the integration of stabilized and VMS methods with data-driven approaches and machine learning. Discussions will also focus on applications of stabilized and VMS methods in biomedical engineering, aerospace (from low subsonic to hypersonic regimes), renewable energy, additive manufacturing, marine and automotive industries, among others. By fostering interdisciplinary collaboration, this mini-symposium will provide a platform for researchers to exchange ideas and discuss cutting-edge advancements in stabilized and VMS methods, high-performance computing (HPC), and software development for complex fluid dynamics applications.