The modeling of multiphase flows with liquid-vapor transition such as cavitating flows, sprays, evaporating and boiling flows has applications in numerous fields of science, for instance meteorology, geophysics, and many sectors of engineering such as aerospace and nuclear technologies. These flows are characterized by complex multiscale phenomena involving the dynamic formation of phase interfaces and inter-phase transfers. Important advances have been made in computational models for the simulation of multiphase flows with phase change, based on various mathematical and physical models and different numerical approaches, e.g. [1,2,3]. Yet there are many open challenges towards the accurate description of the hydro-thermodynamics of these flows in realistic configurations. Some difficulties concern for instance the modeling of non-equilibrium phenomena and metastability in heat and mass transfer processes, and the description of nucleation mechanisms. In some problems it is crucial to take into account the multiscale nature of the process, for example in the description of the atomization of liquid jets into droplets or of surface wettability effects in boiling and evaporating flows. Further difficulties arise in problems involving complex multicomponent flows described by realistic equations of state. The rising complexity of newly developed mathematical and physical models entails numerous challenges in the design of accurate and efficient numerical algorithms and the development of computational tools applicable to complex geometries and to a large range of Mach number regimes. The aim of this minisymposium is to bring together scientists working on computational models for multiphase flows with liquid-vapor phase change to share and exchange ideas, discuss challenges and innovative methods in the field. The minisymposium will be open to a broad spectrum of modeling techniques and numerical approaches.