Structural responses under extreme loading and environmental conditions, such as impact, penetration, explosion, high-speed machining, and manufacture and surface treatment under high temperature and high pressure, have been paid wide attention in the recent years because of the interesting and important phenomena involved and the great challenges to computer modelling and simulation. As localization, damage, fracture, fragmentation and phase transformation occur, the multi-scale and multi-physics phenomena should be fully considered, and new theories and numerical methods are needed to model and simulate the structural responses under extreme loading conditions in accurate and effective ways. This minisymposium aims at providing an opportunity for academic researchers and industrial engineers in the related fields to discuss the recent progress and to promote collaboration. Those who have been working on in the related fields are cordially invited to exchange their ideas and research results in this minisymposium. Presentations are solicited in all subjects related to the model-based simulations of structural responses under extreme conditions, which include but are not limited to the followings: 1) Development of advanced numerical methods, such as meshfree and particle methods, generalized finite element and isogeometric methods, and peridynamics for modelling and simulation of structural responses under extreme conditions 2) Machine learning, data-driven and related approaches for the problems with extreme conditions 3) Simulation-based disaster prediction and mitigation 4) Numerical methods and coupling algorithms for multi-scale and multi-physics processes 5) Large-scale and highly efficient computation for the problems with extreme conditions 6) Coupled Lagrangian-Eulerian and immersed methods for the problems with moving boundaries 7) Inverse solutions and optimization for the problems with extreme conditions 8) Numerical algorithm implementation and simulation software development 9) Verification and validation for computer modelling of extreme events 10) Other related subjects