Verified and validated computational models of hard tissues such as bones and teeth have been shown to be a valuable clinical tool in many applications such as: Prediction of risk of fracture in femurs and vertebrae due to osteoporosis [1], the need for prophylactic surgeries in femurs with metastatic or benign tumors, optimizing patient-specific implants, optimizing 3D printed implants and more. This mini-symposium aims to present recent advances in the application of computational biomechanics of hard tissues with an emphasis on clinical practice, difficulties and opportunities in in-vivo validation of these methods. We aim at bringing together computational biomechanics scientists who share the same topics of interest for fruitful discussions and possible future collaborations.