What are the most influential factors in modeling aneurysmal thrombosis? A sensitivity analysis and validation study
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Thrombosis is a biological response closely related to intracranial aneurysms, and the formation of thrombi inside the aneurysm is an important determinant of outcome after endovascular therapy. As the regulation of thrombosis is immensely complicated and the mechanisms governing thrombus formation are not fully understood, mathematical and computational modeling has been increasingly used to gain insight into thrombosis over the last 30 years. To have a robust computational thrombosis model for possible clinical use in the future, it is essential to assess the model’s reliability through comprehensive sensitivity analysis of model parameters and validation studies based on clinical information of real patients. Here, we conduct a global sensitivity analysis on a previously developed thrombosis model, utilizing thrombus composition, the flow-induced platelet index, and the bound platelet concentration as output metrics. These metrics are selected for their relevance to thrombus stability.
