Modelling Human Skin Morphology and Simulating Transdermal Transport of 50 Chemicals
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Predicting transdermal transport of chemicals remains challenging due to the complex interplay between physicochemical properties and the multilayer structure of human skin. To address this, a multilayer finite-dose model is formulated that incorporates key parameters describing the skin layers and the applied formulation. Numerical simulations are performed to capture concentration profiles and transdermal fluxes. The transport behaviour of 50 chemicals is analysed across different computational skin meshes, enabling a comparison of permeation characteristics. The results reveal distinct uptake behaviour and enable analysis of permeation pathways.
