Numerical Simulation of Transdermal Insulin Delivery Using a Coated Microneedle in a 2D Skin Model
Please login to view abstract download link
In this work, we present a computational model to investigate transdermal insulin delivery using coated microneedles. We developed a skin geometry incorporating a single coated microneedle to analyze insulin release and transport through the skin and evaluate the influence of key transport parameters. The geometry represents the major skin layers: the stratum corneum, viable epidermis, and dermis, including the characteristic morphology of the dermal--epidermal junction. Unstructured grids were used to provide sufficient spatial resolution. We then discretized the diffusion equation using the finite volume method, enabling numerical computation of insulin transport across the skin. The numerical simulations provide insights into the time-dependent release of insulin from the coating and its subsequent transport and distribution across the individual skin layers. Finally, we compared the simulation results with experimental data to evaluate the predictive capability of the model. Both showed a similar overall trend in cumulative insulin release.
