Before market entry every commercial product needs to undergo a certification process, at the end of which an authority confirms that the product has been designed and manufactured according to prevailing environmental and safety standards. Showing compliance to these requirements, typically is a costly and time-consuming process. Therefore, passing this stage as quickly and seamlessly as possible is a key contributor towards having a competitive product on the market at the right time. Consequently, OEMs have a great interest in reducing the costs and time risks associated to the certification process. Hence, they aim for a further extension of computational methods as an accepted means of compliance for aircraft certification. These efforts are often called “simulation-based certification” or “Certification by Analysis” (CbA). DLR has been developing physics-based HPC-software for more than three decades and operates a variety of large-scale testing facilities, including wind tunnels and a fleet of research aircraft. Above that, DLR is a design organization recognized by the German Federal Aviation Office and EASA. All of that enables DLR to develop and validate simulation methods over a broad range of conditions, putting DLR into a promising position to make significant contributions towards a simulation-based certification. Hence, several research activities with respect to CbA have been launched at DLR. Also, DLR joined an international working group on “Certification by Analysis”. Moreover, EASA has shared their view on the topic within a proposal for a Certification Memorandum. It quickly became clear that a profound verification and validation of simulation tools under conditions met during certification is a prerequisite. Based on these requirements, the research focus in the last years has shifted towards enhancing current prediction capabilities by a systematic assessment and quantification of all relevant errors and uncertainties. We would like to give an overview on recent DLR activities in flight physics which aim to support CbA in the future.