Local Sensitivity Analysis of a Thrombosis Model: Towards the Design of an Experiment

  • Thissen, Doris (Eindhoven University of Technology)
  • van de Vosse, Frans (Eindhoven University of Technology)
  • Huberts, Wouter (Eindhoven University of Technology)

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This study aims to conduct a local sensitivity analysis (LSA) on a computational model of thrombosis to support the design of an in vitro experiment. The LSA is performed on a continuum model that combines the Navier-Stokes equations, describing the blood hemodynamics, with convection-diffusion-reaction equations, describing the concentrations of seven thrombus-related species. The input parameters considered are the reaction coefficients for unactivated platelets binding to the damaged wall, activated platelets binding to the damaged wall, and activated platelets binding to each other. The discussion and significance of the results are described in the abstract.