An open-source high resolution reacting flow solver OpenCFD-Comb is developed by the authors, and the high-order finite difference method is used to discretize the compressible Navier-Stokes equations that account for thermodynamic nonequilibrium and chemical reactions. High-order shock-capturing schemes developed by the authors, such as OMP[1] and hybrid schemes[2], are used to discretize the inviscous terms. Both thermodynamic equilibrium and thermodynamic nonequilibrium (two-temperature model) are considered in this code. By using OpenCFD-Comb, direct numerical simulations are conducted to study the interaction between an oblique shock wave and a turbulent boundary layer with high-enthalpy chemical nonequilibrium effects[3]. The investigation is conducted at a freestream Mach number of 10, where a shock wave inclined at 17-degree impinges on a flat-plate turbulent boundary layer flows. The DNS results shows that the high temperature reactions lead to a reduction in the mean temperature, which in turn causes an earlier transition to turbulence. In the shock-boundary layer interaction region, the reactive case exhibits a smaller separation bubble. OpenCFD-Comb is open source and can be download in the website www.opencfd.cn or the link: http://pan.baidu.com/s/1slfC5Yl.