Introduction: Cholangiocarcinoma is the most common biliary tract cancer. Surgical resection is considered the main curative treatment. One of the main complications of major hepatectomy is portal vein thrombosis which occurs in about 10% of patients and can be fatal. Hemodynamic shear appears to play a role in the development of thrombosis. Materials and Methods: The cohort is composed of 17 patients who underwent hepatectomy with portal vein resection. 7 of them developed thrombosis following surgery (cases versus 10 controls). All patient geometries are segmented from post-operative scans. A third group is created based on virtual surgeries performed on pre-operative CT scans of the cases, with a vascular graft inserted instead of simple anastomosis. This group is referred to as virtual surgery. Computational fluid dynamics (CFD) simulations are conducted with the finite-element code FELiScE. Blood is modeled as a Newtonian fluid. The inlet boundary condition is based on an averaged inflow measured on 3 patients with an ultrasound probe (MiraQTM, Medistim, Norway) and distributed with the ratio Splenic Vein:Superior Mesenteric Vein = 1:2. The imposed inlet velocity is a parabolic profile. 3-element Windkessel models are implemented at the outlets based on the subtending liver volume distribution. The simulations are post-processed with in-house Python scripts to delineate flow features that are different among the groups. Results: A significantly higher mean shear rate is found in the region downstream of the resection for the cases. A trend is observed of larger regions of negative shear rate gradient in the cases, a fluid dynamic marker that has been reported as prothrombotic. Discussion and Conclusions: Preliminary work on finding relevant biomarkers for prediction of thrombosis in the context of liver surgery is presented. Shear appears as an essential parameter in the onset of the complication. Current work aims at modeling thrombus formation in the portal vein geometries through the extension of a recently developed model.