Ensuring the long-term performance and safety of adhesive bonds under cyclic mechanical loading and environmental influences such as temperature and humidity requires advanced computational models. We present a simulation method that enables lifetime prediction of hygro-thermo-mechanically loaded adhesive joints. The treatment of coupled multi-physics problems is addressed and a novel constitutive model for adhesives is proposed. A convolution-based viscoelastic law incorporating the effects of temperature and moisture through the time-temperature-concentration superposition principle is coupled with a continuum damage mechanics approach to model adhesive degradation. The damage evolution equation includes contributions from creep damage [1], fatigue damage [2] and moisture-induced aging [3]. Moreover, the model is calibrated using inverse parameter identification and numerical simulations are compared with experimental results for validation. [1] Kachanov LM. Rupture time under creep conditions. Int J Fract 1999;97:11-8. [2] Lemaitre J. Damage modelling for prediction of plastic or creep fatigue failure in structures. In: Transactions of the 5th International Conference on Structural Mechanics in Reactor Technology (SMiRT 5); 1979 Aug 13-17; Berlin, Germany. Vol L. Berlin: SMiRT; 1979. [3] Johlitz M, Lion A. Chemo-thermomechanical ageing of elastomers based on multiphase continuum mechanics. Contin Mech Thermodyn 2013:25(5):605-24.